Effectiveness of immunochromatography method in lee for Helicobacter Pylori diagnostic in patients with dyspepsia Eficacia del método de inmunocromatografía en heces para el diagnóstico de Helicobacter Pylori en pacientes con dispepsia: evaluación preliminar

Abstract

Helicobacter pylori infection is considered one of the most important emerging diseases of this century, which is closely related with gastroduodenal tract diseases and as a predisposing factor for gastric carcinoma. For diagnosis purpose, it have been used invasive and noninvasive tests, among the latter the fecal immunochromatography, which qualitatively detect pathogen’s antigens. The aim of this study was to determine the effectiveness of this method for diagnosis of infection with H. pylori in dyspeptic patients from a hospital in Cundinamarca. Methods: We conducted a preliminary study to evaluate a diagnostic test, for which we used patients with dyspepsia history and gastric biopsy report in their medical record. Stool samples were evaluated and through the rapid test SD Bio Line H. pylori Ag™, we determined the presence of fecal H. pylori antigens. We evaluated a total of 33 patients: 48.4% men and 51.5% women, the sensitivity was 30% and specificity of 84.62%. The positive predictive value calculated was 75% and the negative predictive value was 44%. The specificity calculated for the test is comparable to that found in the literature; however, due to the reliability index’s interval showed, it would take more evidence to increase the reliability of the results shown here.