Evaluation of symptoms in children and adolescents with cancer: comprehensive review
Evaluación de síntomas en niños y adolescentes con cáncer: revisión integrativa
Main Article Content
Children and teenagers diagnosed with cancer have to face a series of changes in the different aspects of their life, and also experience multiple physical and psychosocial symptoms as a cause of the disease and its treatment, which affects their own life and their caregiver life quality. Objective: Investigate the current state of research related to the evaluation of symptoms in children and teenagers with cancer. Method: Comprehensive review about the scientific production in English, Spanish, and Portuguese languages generated between 2007 and 2018 in the databases Embase, Ovid, Medline, Pubmed, Science Direct and Scielo. 50 articles were included, which provide information about the evaluation of symptoms in the pediatric population diagnosed with cancer. Results: Researches about tools that evaluate the manifestation of symptoms, adapted and validated to pediatric population are limited. Conclusions: Children and teenagers with cancer show symptoms during different phases of the disease and treatment. The studies are scarce about the symptoms in the local context, therefore it is required to validate specific scales for this population, describe the symptoms including perceived clinical and life quality variables that can be used to orientate opportune interventions to handle the symptoms.
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Organización Mundial de Salud (OMS). El cáncer infantil. [Internet]. 2016. [consultado 25 de abril de 2017]. Disponible en: http://www.who.int/cancer/es/
Organización Panamericana de la Salud (OPS). El cáncer infantil en las Américas. [Internet]. 2014. [consultado 25 de abril de 2017]. Disponible en: https://www.paho.org/hq/dmdocuments/2014/OPS-Nota-Informativa-Cancer-Infantil-2014.pdf
Huertas Quintero J, Rivillas García J, Vera Rey A, Roldán Sánchez O, Ospina Martínez M. Guía metodológica para el observatorio Nacional de Cáncer [Internet]. 2015. [consultado 27 de Mayo de 2017]. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/ED/GCFI/guia-ross-cancer.pdf
Piñeros M, Gamboa O. Suárez A. Mortalidad por cáncer infantil en Colombia durante 1985 a 2008. Revista Panamericana de Salud Pública. 2011; 30(1):15–21.
Hockenberry M, Hooke MC. Symptom clusters in children with cancer. Seminars in oncology nursing, 2007; 23(2):152-157. DOI: https://doi.org/10.1016/j.soncn.2007.01.001
Barz Leahy A, Feudtner C, Basch E. Symptom Monitoring in Pediatric Oncology Using Patient-Reported Outcomes: Why, How, and Where Next. Patient. 2018; 11(2):147-153. DOI: https://doi.org/10.1007/s40271-017-0279-z
Collins JJ, Byrnes ME, Dunkel IJ, Lapin J, Nadel T, Thaler HT, Polyak T, Rapkin B, Portenoy RK. The measurement of symptoms in children with cancer. Journal of Pain Symptom Management. 2000; 19(5): 363–77. DOI: https://doi.org/10.1016/S0885-3924(00)00127-5
Collins JJ , Devine TD, Dick GS, Johnson EA, Kilham HA, Pinkerton CR, Stevens MM, Thaler HT, Portenoy RK. The measurement of symptoms in young children with cancer: The validation of the memorial symptom assessment scale in children aged 7-12. Journal of Pain Symptom Management. 2002; 23(1): 10–6. DOI: https://doi.org/10.1016/S0885-3924(01)00375-X
Abu-Saad Huijer H, Sagherian K, Tamim H. Quality of life and symptom prevalence as reported by children with cancer in Lebanon. European Journal of Oncology Nursing. 2013; 17(6): 704–710. DOI: https://doi.org/10.1016/j.ejon.2013.09.004
Arslan FT, Basbakkal Z, Kantar M. Quality of life and chemotherapy-related symptoms of Turkish cancer children undergoing chemotherapy. Asian Pacific Journal of Cancer Prevention. 2013; 14(3): 1761–1768. DOI: https://doi.org/10.7314/APJCP.2013.14.3.1761
Rodgers C, Hooke MC, Ward J, Linder LA. Symptom Clusters in Children and Adolescents with Cancer. Seminars in Oncology Nursing. 2016; 32(4): 394–404. DOI: https://doi.org/10.1016/j.soncn.2016.08.005
Linder LA, Al-Qaaydeh S, Donaldson G. Symptom Characteristics Among Hospitalized Children and Adolescents With Cancer. Cancer Nursing. 2017; 41(1): 23-32. DOI: https://doi.org/10.1097/NCC.0000000000000469
Erickson J, MacPherson CF, Ameringer S, Baggott C, Linder L, Stegenga K. Symptoms and symptom clusters in adolescents receiving cancer treatment: A review of the literature. International Journal of Nursing Studies. 2013; 50(6): 847-69 DOI: https://doi.org/10.1016/j.ijnurstu.2012.10.011
De Chico Cicogna E, Castanheira Nascimento L, García de Lima RA. Children and Adolescents with Cancer: Experiences with Chemotherapy. Revista Latino-Americana de Enfermagem. 2010; 8(5):864-72. DOI: https://doi.org/10.1590/S0104-11692010000500005
Vatne TM, Slaugther L, Ruland CM. How Children with Cancer Communicate and Think About Symptoms. Journal of Pediatric Oncology Nursing. 010; 27(1) 24–32. DOI: https://doi.org/10.1177/1043454209349358
Van Cleve L, Munoz CE, Savedra M, Riggs M, Bossert E, Grant M, Adlard K. Symptoms in Children With Advanced Cancer. Child and Nurse reports. Journal of Pediatric Oncology Nursing. 2012; 29(1): 28–36. DOI: https://doi.org/10.1177/1043454211432295
Baggott C, Cooper BA, Marina N, Matthay KK, Miaskowski C. Symptom Cluster Analyses Based on Symptom Occurrence and Severity Ratings Among Pediatric Oncology Patients During Myelosuppressive Chemotherapy. Cancer Nursing. 2012; 35(1):19–28. DOI: https://doi.org/10.1097/NCC.0b013e31822909fd
Williams PD, Piamjariyakul U, Shanberg R, Williams AR. Monitoring and Alleviation of Symptom Occurrence and Severity Among Thai Children and Adolescents During Cancer Treatments. Journal of Pediatric Oncology Nursing. 2015: 1-12. DOI: https://doi.org/10.1177/1043454214563754
Whittemore R, Knafl K. The integrative review: updated methodology. Journal of Advanced Nursing. 2005; 52(5):546–553 DOI: https://doi.org/10.1111/j.1365-2648.2005.03621.x
Pinheiro LC, McFatrich M, Lucas N, Walker JS, Withycombe JS, Hinds PS, Sung L, Tomlinson D, Freyer DR, Mack JW, Baker JN, Reeve BB. Child and adolescent self-report symptom measurement in pediatric oncology research: a systematic literature review. Quality of life research. 2018; 27(2): 291-319. DOI: https://doi.org/10.1007/s11136-017-1692-4
Baggott C, Dodd M, Kennedy C, Marina N, Miaskowski C. Multiple Symptoms in Pediatric Oncology Patients: A Systematic Review. Journal of Pediatric Oncology Nursing. 2009; 26(6): 325–339. DOI: https://doi.org/10.1177/1043454209340324
Fernandes A, Batalha L, Perdigao A, De Campos C, Nascimento L, Jacob E. Validação cultural do Adolescent Pediatric Pain Tool (APPT) em crianças portuguesas com cancro. Revista de Enfermagem Referência. 2015; 4(4): 99-105. DOI: https://doi.org/10.12707/RIV14007
Dupuis LL, Ethier MC, Tomlinson D, Hesser T, Sung L. A systematic review of symptom assessment scales in children with cancer. BiomedCentral Cancer. 2012; 26(12): 430 DOI: https://doi.org/10.1186/1471-2407-12-430
Rodrigues Nunes MD, Miyauti Silva MC, Leonardo Rocha E, García de Lima RA, Castanheira Nascimento L. Measurement of fatigue in children and adolescents with cancer: an integrative review. Text & Context Nursing Journal. 2014; 23(2): 492-501. DOI: https://doi.org/10.1590/0104-07072014003960011
Portenoy RK, Thaler HT, Kornblith AB, McCarthy Lepore J, Friedlander-Klar H, Kiyasu E, Sobel K, Coyle N, Kemeny N, Norton L, Scher H. The Memorial Symptom Assessment Scale: an instrument for the evaluation of symptom prevalence, characteristics and distress. European Journal of Cancer. 1994; 30(9):1326–1336. DOI: https://doi.org/10.1016/0959-8049(94)90182-1
Yeh CH, Chiang YC, Chie LC, Lin L, Yang CP, Chuang HL. Symptom Clustering in Older Taiwanese Children with Cancer. Oncology Nursing Forum. 2008; 35(2): 273-281. DOI: https://doi.org/10.1188/08.ONF.273-281
William Li HC, Williams PD, Lopez V, Kwang Chung JO, Ying Chiu S. Relationships among therapy-related symptoms, depressive symptoms, and quality of life in Chinese children hospitalized with cancer: an exploratory study. Cancer Nursing. 2013; 36(5):346–54. DOI: https://doi.org/10.1097/NCC.0b013e31824062ec
Abu-Saad H, Sagherian K, Tamim H. Validation of the Arabic Version of the Memorial Symptom Assessment Scale among Lebanese Cancer Patients. Journal of Pain Symptom Management. 2015; 50(4):559–65. DOI: https://doi.org/10.1016/j.jpainsymman.2014.08.014
Ameringer S, Elswick RK, Shockey DP, Dillon R. A Pilot Exploration of Symptom Trajectories in Adolescents With Cancer During Chemotherapy. Cancer Nursing. 2013; 36 (1): 60-71. DOI: https://doi.org/10.1097/NCC.0b013e318250da1a
Atay S, Conk Z, Bahar Z. Identifying symptom clusters in paediatric cancer patients using the Memorial Symptom Assessment Scale. European Journal of Cancer Care. 2012; 21(4):460–8. DOI: https://doi.org/10.1111/j.1365-2354.2012.01324.x
Baggott C, Baird J, Hinds P, Ruland CM. Miaskowski C. Evaluation of Sisom: A computer-based animated tool to elicit symptoms and psychosocial concerns from children with cancer. European Jorunal of Oncology Nursing. 2015; 19(4): 359–369. DOI: https://doi.org/10.1016/j.ejon.2015.01.006
Hedén L, Pöder, U, Von Essen L, Ljungman G. Parents' Perceptions of Their Child's Symptom Burden During and After Cancer Treatment. Journal of Pain and Symptom management. 2013; 46(3): 366-375. DOI: https://doi.org/10.1016/j.jpainsymman.2012.09.012
Williams PD, Williams AR, Kelly KP, Dobos C, Gieseking A, Connor R, Ridder L, Potter N, Del Favero D. A symptom checklist for children with cancer. The Therapy-Related Symptom Checklist-Children. Cancer Nursing. 2012; 35(2): 89-98. DOI: https://doi.org/10.1097/NCC.0b013e31821a51f6
Williams PD, Robinson, J, Williams AR. Symptom occurrence and severity on the therapy-related symptom checklist for children among Hispanic pediatric oncology outpatients. Cancer Nursing. 2014; 37(3):12-20. DOI: https://doi.org/10.1097/NCC.0b013e3182948438
Hyslop S, Dupuis L, Baggott C, Dix D, Gibson P, Kuczynski S, Johnston, D, Orsey A, Portine C, Price V, Spiegler B, Tomlinson D, Vanan M, Tomlinson G, Sung L. Validation of the Proxy Version of Symptom Screening in Pediatrics Tool in Children Receiving Cancer Treatments. 2018. 1-6. DOI: https://doi.org/10.1016/j.jpainsymman.2018.03.025
Wang J, Jacobs D, Dewalt DA, Stem E, Gross H, Hinds PS. A Longitudinal Study of PROMIS Pediatric Symptom Clusters in Children Undergoing Chemotherapy. Journal of Pain and Symptom Management. 2018; 55(2): 329-367. DOI: https://doi.org/10.1016/j.jpainsymman.2017.08.021
Reeye BB, Edwards LJ, Jaeger BC, Hinds PS, Dampier C, Gipson D, Selewski DT, Troost JP. Thissen D, Barry V. Gross HE, DeWalt DA. Assessing responsiveness over time of the PROMIS pediatric symptom and function measures in cancer, nephrotic syndrome, and sickle cell disease. Quality of Life Research. 2018. 27: 249-257. DOI: https://doi.org/10.1007/s11136-017-1697-z
Hockenberry MJ, Hooke MC, Gregurich M, McCarthy K, Sambuco G, Krull K. Symptom Clusters in Children and Adolescents Receiving Cisplatin, Doxorubicin, or Ifosfamide. Oncology Nursing Forum. 2010; 37(1): 16-27. DOI: https://doi.org/10.1188/10.ONF.E16-E27
Kim B, White K, Patterson P. Understanding the experiences of adolescents and young adults with cancer: A meta-synthesis. European Journal of Oncology Nursing. 2016; 24: 39-53. DOI: https://doi.org/10.1016/j.ejon.2016.06.002
Kestler SA, LoBiondo-Wood G. Review of Symptom Experiences in Children and Adolescents With Cancer. Cancer Nursing. 2012; 35(2): 31-49. DOI: https://doi.org/10.1097/NCC.0b013e3182207a2a
Yeh CH, Wang CH, Chiang YC, Lin L, Chien LC. Assessment of Symptoms Reported by 10- to 18-Year-Old Cancer Patients in Taiwan. Journal of Pain and Symptom Management. 2009; 38(5):738-746. DOI: https://doi.org/10.1016/j.jpainsymman.2009.04.023
Linder LA, AmeringerS, Baggott C, Erickson J, Machpherson C, Rodgers C and Stegenga K. Measures and methods for symptom and symptom cluster assessment in Adolescents and Young Adults with Cancer. Seminars in Oncology Nursing. 2015; 31(3): 206-215. DOI: https://doi.org/10.1016/j.soncn.2015.05.002
Miyauti da Silva MC, Lopes Júnior LC, Castanheira Nascimento L, García de Lima RA. Fatiga en niños y adolescentes con cáncer bajo la perspectiva de los profesionales de salud. Revista Latino-Americana Enfermagem. 2016; 24: 1-10.
Tomlinson D, Hinds PS, Ethier MC, Ness KK, Zupanec S, Sung L. Psychometric Properties of Instruments Used to Measure Fatigue in Children and Adolescents With Cancer: A Systematic Review. Journal of Pain Symptom Management. 2013; 45(1): 83–91. DOI: https://doi.org/10.1016/j.jpainsymman.2012.02.010
McCulloch R, Hemsley J, Kelly P. Symptom management during chemotherapy. Paediatrics and child health. 2018; 28(4): 189-195. DOI: https://doi.org/10.1016/j.paed.2018.02.003
Wolfe J, Orellana L, Ullrich C, Cook F, Kang TI, Rosenberg A, Geyer R, Feudtner C, Dussel V. Symptoms and Distress in Children with Advanced Cancer: Prospective Patient-Reported Outcomes From the PediQUEST Study. Journal of Clinical Oncology. 2015; 33 (17): 1928–1935. DOI: https://doi.org/10.1200/JCO.2014.59.1222
Miller E, Jacob E, Hockenberry MJ. Nausea, Pain, Fatigue, and Multiple Symptoms in Hospitalized Children with Cancer. Oncology Nursing Forum. 2011; 38(5): 82-93 DOI: https://doi.org/10.1188/11.ONF.E382-E393
Hooke MC, Garwick AW, Gross CR. Fatigue and Physical Performance in Children and Adolescents Receiving Chemotherapy. Oncology Nursing Forum. 2011; 38 (6): 649-657. DOI: https://doi.org/10.1188/11.ONF.649-657
Hockenberry M. Symptom Research in Children with Cancer: One Researcher’s Journey. Virginia Henderson Global Nursing Repository. 2017.
Hockenberry MJ, Hooke MC, Rodgers C, Taylor O, Koerner KM, Mitby P, Moore I Scheurer ME, Pan W. Symptom Trajectories in Children Receiving Treatment for Leukemia: A Latent Class Growth Analysis with Multitrajectory Modeling. Journal of Pain and Symptom Management. 2017; 54(1): 1-8. DOI: https://doi.org/10.1016/j.jpainsymman.2017.03.002
Miaskowski, C. Future directions in symptom cluster research. Seminars in Oncology Nursing. 2016; 32(4): 405-415. DOI: https://doi.org/10.1016/j.soncn.2016.08.006
Lopes Júnior LC, De Omena Bomfim E, Castanheira Nascimento L, Pereira da Silva G, García de Lima RA. Theory of unpleasant symptoms: support for the management of symptoms in children and adolescents with cancer. Revista Gaúcha de Enfermagem. 2015; 36(3):109-112. DOI: https://doi.org/10.1590/1983-1447.2015.03.51465
Tsimicalis A, Rennick J, Stinson J, Le May S, Louli J, Choquette A, Treheme S, Berube S, Yoon S, Ruland C. Usability testing of an interactive communication tool to help children express their cancer symptoms. Journal of Pediatric Oncology Nursing. 2018: 1-12. DOI: https://doi.org/10.1177/1043454218777728
Tomlinson L, Dupuis LL, Gibson D, Johnston DL, Portwine C, Baggott C, Zupanec S, Watson J, Spiegler B, Kuczynski S, Macartney G, Sung L. Initial development of the Symptom Screening in Pediatrics Tool (SSPedi). Support Care Cancer. 2014; 22: 71-75. DOI: https://doi.org/10.1007/s00520-013-1945-x
O’Sullivan L, Dupuis L, Gibson P, Johnston DL, Baggott C, Portwine C, Spiegler B, Kuczynski S, Tomlinson S, Van Otterloo S, Tomlinson GA, Sung L. Refinement of the Symptom Screening in Pediatrics Tool (SSPedi). British Journal of Cancer. 2014; 111: 1262-1268. DOI: https://doi.org/10.1038/bjc.2014.445
Johnston DL, Hyslop, S, Tomlinson D, Baggott C, Gibson P, Orsey A, Dix D, Pirce V, Vanan M, Portwine C, Kuczynski S, Spiegler B, Tomlinson GA, Dupuis LL, Sung L. Describing symptoms using the Symptom Screening in Pediatrics Tool in hospitalized children with cancer and hematopoietic stem cell transplant recipients. Cancer Medicine. 2018; 7(5):1750–1755. DOI: https://doi.org/10.1002/cam4.1433
Linder L, Macpherson CF, Stegenga K, Ameringer S, Erickson J, Hinds P, Fugate Woods, N. Feasibility and acceptability of an iPad application to explore symptom clusters in Adolescents with cáncer. Virginia Henderson Global Nursing e-Repository. 2018.
Wang J, Yao N, Liu Y, Geng Z, Wang Y, Shen N, Zhang X, Shen M, Yuan C. Development of a Smartphone Application to Monitor Pediatric Patient-Reported Outcomes. Computers, Informatics, Nursing. 2017; 35 (11): 590-598. DOI: https://doi.org/10.1097/CIN.0000000000000357
Menard JC, Hinds PS, Jacobs SS, Cranston K, Wang J, DeWalt DA, Gross HE. Feasibility and Acceptability of the Patient-Reported Outcomes Measurement Information System Measures in Children and Adolescents in Active Cancer Treatment and Survivorship. Cancer Nursing. 2014; 37(1): 66-74. DOI: https://doi.org/10.1097/NCC.0b013e3182a0e23d
Humphreys J, Janson S, Donesky D, Dracup K, Lee K, Puntillo K, Faucett J, Aouizerat B, Miaskowki C, Baggott C, Carrieri V, Barger M, Franck L, Kennedy C. A Middle Range Theory of Symptom Management. En: Smith MJ, Liehr PR. Middle Range Theory for Nursing. Third edition. New York: Springer Publishing Company. 2014.